Microcrystalline cellulose vegetable capsule carbohydrate gum cellulose purified water magnesium stearate vegetable grade silica.
Theracurmin containing 90 mg of curcumin.
The investigators expect that the volunteers receiving the curcumin supplement will show less evidence of decline after 18 months than those receiving the placebo.
The intervention is twice daily dosage of theracurmin 90 mg capsules.
Attention was assessed as a secondary outcome.
Subjects will be randomly assigned to one of two treatment groups.
Forty subjects age 51 84 years were randomized to a bioavailable form of curcumin theracurmin containing 90 mg of curcumin twice daily n 21 or placebo n 19 for 18 months.
1 capsule equivalent to 260 mg.
Bioavailable curcumin normal aging memory cognition positron emission tomography highlights this is the first long term 18 months double blind placebo controlled trial of a bioavailable form of curcumin theracurmin containing 90 mg of curcumin twice daily in non demented adults.
Theracurmin hp capsules containing 90 mg curcumin each that will be taken as one capsule twice daily for 6 months.
6 capsules equivalent to 180 mg curcumin.
Either a placebo twice daily or the curcumin supplement theracurmin containing 90 mg of curcumin.
This same dose was used in a successful trial of patients with mild cognitive impairment.
Blood samples were collected at regular intervals.
The experimental group took theracurmin containing 90 mg of curcumin twice a day ie 180 mg curcumin day for 18 months.
The study lasted for 3 weeks.
The dosage of curcumin from each supplement type was not equal.
The following tests were used to assess cognitive performance.
Theracurmin is a novel preparation of turmeric that utilizes patented colloidal dispersion technology to enhance bioavailability and dramatically increase curcumin levels in the blood unlike other forms of curcumin theracurmin is water dispersible meaning it dissolves quickly and maintains solubility over time thereby improving curcumin s overall absorption.
The experimental group took theracurmin containing 90 mg of curcumin twice daily i e 180 mg curcumin day for 18 months.
Individuals were asked not to consume curcumin containing food for more than 7 days prior to the study.
Cognitive performance was assessed through verbal and visual testing.